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Primobolan (methenolone) is a mild anabolic‑androgenic steroid available as oral acetate or injectable enanthate, primarily used in research and historically investigated for muscle‑wasting and anemia, but it is not an approved therapeutic drug in most countries.
- CAS 303‑42‑4 identifies both acetate and enanthate forms.
- Forms: oral methenolone acetate tablets & injectable methenolone enanthate (Primobolan Depot).
- Effect: promotes protein synthesis with relatively low androgenic side effects.
Primobolan Depot Injection
Primobolan (Methenolone) – Quick Reference
1. Chemical Identity
| Property | Details |
|---|---|
| Generic name | Methenolone (also spelled Metenolone) |
| Brand name | Primobolan |
| CAS number | 303‑42‑4 |
| Classification | Androgenic‑anabolic steroid (AAS) |
| Molecular formula | C₂₀H₃₀O₂ (acetate) / C₂₅H₃₈O₃ (enanthate) |
2. Available Forms
- Methenolone acetate – oral tablets (often 5 mg).
- Methenolone enanthate – injectable oil solution, marketed as Primobolan Depot.
Both are listed as analytical reference standards and research chemicals12.
3. Pharmacological Actions
- Increases retention of nitrogen, potassium, phosphorus → supports protein synthesis and lean‑mass accrual3.
- Exhibits mild androgenic activity compared with many other AAS, resulting in a comparatively lower incidence of typical steroid‑related side effects.
4. Historical / Clinical Uses
| Context | Reported use |
|---|---|
| Research | Reference standard for analytical chemistry; animal dosing studies (≈10 mg kg⁻¹, 3×/week)3. |
| Medical (historical) | Investigated for muscle‑wasting diseases, refractory anemia, and urological conditions in Japan (1960s)7. |
| Japanese drug directory | Claims to alleviate severe physical exhaustion and strengthen bone by storing calcium, phosphorus, and nitrogen8. |
| Non‑medical / performance | Frequently misused for bodybuilding due to its anabolic profile. |
Note: Primobolan is not approved for therapeutic use in most jurisdictions; it is sold mainly as a research chemical1.
5. Typical Research Dosage (Animal Studies)
- 10 mg kg⁻¹ administered three times per week (intramuscular) demonstrated significant gains in total body nitrogen and muscle protein3.
Human dosing regimens are undocumented in peer‑reviewed literature because of its unapproved status.
6. Side‑Effect Profile
- Androgenic: Lower risk of virilization, acne, and hair loss compared with stronger AAS, but still possible (hair loss noted in video source10).
- Endocrine: Can suppress natural testosterone production → requires post‑cycle therapy.
- Hepatic: Generally non‑hepatotoxic (unlike 17‑alpha‑alkylated steroids), but liver enzymes should be monitored in prolonged use.
7. Regulatory Status
- Classified as a research chemical and reference standard; not a scheduled pharmaceutical in most countries.
- Possession for personal use may be restricted under anabolic‑steroid control laws.
8. Quick Facts
- CAS: 303‑42‑4
- Forms: acetate (oral) & enanthate (injectable)
- Mild androgenic profile → popular among those seeking “clean” anabolic effects.
- Primary use today: scientific research; historical medical applications are largely obsolete.
Bottom line: Primobolan (methenolone) is a mild anabolic steroid available in oral and injectable ester forms, historically explored for muscle‑wasting and anemia but now primarily a research chemical due to lack of regulatory approval.